Amphiphilic P(OEGMA-co-DIPAEMA) Hyperbranched Copolymer/Magnetic Nanoparticle Hybrid Nanostructures by Co-Assembly
نویسندگان
چکیده
This work presents the utilization of amphiphilic poly(oligo(ethylene glycol) methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched (HB) copolymers, forming polymeric aggregates in aqueous media, as building nanocomponents and nanocarriers for entrapment magnetic cobalt ferrite nanoparticles (CoFe2O4, MNPs), hydrophobic drug curcumin (CUR) their domains. Dynamic light scattering (DLS) cryogenic transmission electron microscopy (cryo-TEM) techniques were used to evaluate multifunctional hybrid nanostructures formed media by co-assembly components solution properties. Magnetic (MNPs) or MNPs/CUR co-assembled effectively with pre-existing polymer aggregates, leading well-defined nanostructures. Magnetophoresis experiments revealed that retain properties MNPs after copolymers. The demonstrate a significant colloidal stability under physiological conditions. Furthermore, MNPs/CUR-loaded displayed considerable fluorescence demonstrated spectroscopy. These could be promising candidates delivery bio-imaging applications.
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ژورنال
عنوان ژورنال: Nanomanufacturing
سال: 2022
ISSN: ['2673-687X']
DOI: https://doi.org/10.3390/nanomanufacturing2010004